Theodore Towse
Last active: 4/25/2016

Anisotropic Smoothing Improves DT-MRI-Based Muscle Fiber Tractography.

Buck AK, Ding Z, Elder CP, Towse TF, Damon BM
PLoS One. 2015 10 (5): e0126953

PMID: 26010830 · PMCID: PMC4444336 · DOI:10.1371/journal.pone.0126953

PURPOSE - To assess the effect of anisotropic smoothing on fiber tracking measures, including pennation angle, fiber tract length, and fiber tract number in the medial gastrocnemius (MG) muscle in healthy subjects using diffusion-weighted magnetic resonance imaging (DW-MRI).

MATERIALS AND METHODS - 3T DW-MRI data were used for muscle fiber tractography in the MG of healthy subjects. Anisotropic smoothing was applied at three levels (5%, 10%, 15%), and pennation angle, tract length, fiber tract number, fractional anisotropy, and principal eigenvector orientation were quantified for each smoothing level.

RESULTS - Fiber tract length increased with pre-fiber tracking smoothing, and local heterogeneities in fiber direction were reduced. However, pennation angle was not affected by smoothing.

CONCLUSION - Modest anisotropic smoothing (10%) improved fiber-tracking results, while preserving structural features.

MeSH Terms (8)

Adult Anisotropy Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Female Humans Male Muscle Fibers, Skeletal

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