Jeff Reese
Last active: 1/7/2021

Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial.

Clyman RI, Kaempf J, Liebowitz M, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, Farooqi A, Katheria A, Sauberan J, Singh J, Nelson K, Wickremasinghe A, Dong L, Hassinger DC, Aucott SW, Hayashi M, Heuchan AM, Carey WA, Derrick M, Fernandez E, Sankar M, Leone T, Perez J, Serize A, PDA-TOLERATE Trial Investigators
J Pediatr. 2021 229: 283-288.e2

PMID: 32979387 · PMCID: PMC7855529 · DOI:10.1016/j.jpeds.2020.09.047

In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required <10 days of intubation. However, in infants requiring intubation for ≥10 days, prolonged PDA exposure (≥11 days) was associated with an increased risk of moderate/severe BPD.

Copyright © 2020 Elsevier Inc. All rights reserved.

MeSH Terms (11)

Bronchopulmonary Dysplasia Ductus Arteriosus, Patent Female Humans Infant, Newborn Intubation, Intratracheal Male Prospective Studies Respiration, Artificial Severity of Illness Index Time Factors

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