Seth Karp
Last active: 4/11/2016

Minimising cold ischaemic time is essential in cardiac death donor-associated liver transplantation.

Karp SJ, Johnson S, Evenson A, Curry MP, Manning D, Malik R, Lake-Bakaar G, Lai M, Hanto D
HPB (Oxford). 2011 13 (6): 411-6

PMID: 21609374 · PMCID: PMC3103098 · DOI:10.1111/j.1477-2574.2011.00307.x

BACKGROUND - An important issue in the transplantation of livers procured from cardiac death donors (CDDs) concerns why some centres report equivalent outcomes and others report inferior outcomes in transplantations using CDD organs compared with standard criteria donor (SCD) organs. Resolving this discrepancy may increase the number of usable organs.

OBJECTIVES - This study aimed to test whether differences in cold ischaemic time (CIT) are critical during CDD organ transplantation and whether such differences might explain the disparate outcomes.

METHODS - Results of CDD liver transplants in our own centre were compared retrospectively with results in a matched cohort of SCD liver recipients. Endpoints of primary non-function (PNF) and ischaemic cholangiopathy (IC) were used because these outcomes are clearly associated with CDD organ use.

RESULTS - In 22 CDD organ transplants, CIT was a strong predictor of PNF or IC (P = 0.021). Minimising CIT in CDD organ transplants produced outcomes similar to those in a matched SCD organ transplant cohort at our centre and in SCD organ transplant results nationally (1- and 3-year graft and patient survival rates: 90.9% and 73.3% vs. 77.6% and 69.2% in CDD and SCD grafts, respectively. A review of the published literature demonstrated that centres with higher CITs tend to have higher rates of PNF or IC (correlation coefficient: 0.41).

CONCLUSIONS - These findings suggest that a targeted effort to minimise CIT might improve outcomes and allow the safer use of CDD organs.

© 2011 International Hepato-Pancreato-Biliary Association.

MeSH Terms (22)

Adult Boston Chi-Square Distribution Cold Ischemia Death Female Graft Survival Humans Liver Transplantation Male Middle Aged Primary Graft Dysfunction Reperfusion Injury Retrospective Studies Risk Assessment Risk Factors Survival Analysis Survival Rate Time Factors Tissue Donors Treatment Outcome Young Adult

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