A circadian clock nanomachine that runs without transcription or translation.

Egli M, Johnson CH
Curr Opin Neurobiol. 2013 23 (5): 732-40

PMID: 23571120 · PMCID: PMC3735861 · DOI:10.1016/j.conb.2013.02.012

The biochemical basis of circadian timekeeping is best characterized in cyanobacteria. The structures of its key molecular players, KaiA, KaiB, and KaiC are known and these proteins can reconstitute a remarkable circadian oscillation in a test tube. KaiC is rhythmically phosphorylated and its phospho-status is a marker of circadian phase that regulates ATPase activity and the oscillating assembly of a nanomachine. Analyses of the nanomachines have revealed how their timing circuit is ratcheted to be unidirectional and how they stay in synch to ensure a robust oscillator. These insights are likely to elucidate circadian timekeeping in higher organisms, including how transcription and translation could appear to be a core circadian timer when the true pacemaker is an embedded biochemical oscillator.

Copyright © 2013 Elsevier Ltd. All rights reserved.

MeSH Terms (7)

Animals Bacterial Physiological Phenomena Bacterial Proteins Circadian Clocks Circadian Rhythm Cyanobacteria Nanomedicine

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