Cycloheximide inhibits light-induced phase shifting of the circadian clock in Neurospora.

Johnson CH, Nakashima H
J Biol Rhythms. 1990 5 (2): 159-67

PMID: 2133125 · DOI:10.1177/074873049000500207

Cycloheximide inhibits light-induced phase shifting of the circadian clock and protein synthesis in Neurospora. Light resetting is not inhibited in mutants whose protein synthesis is resistant to cycloheximide. When light and cycloheximide are presented together at various circadian phases, the final phase shift is always determined by cycloheximide. This dual-treatment phase response curve approach may be useful for other studies using pharmacological treatments to analyze clock pathways. Taken together, the results suggest that synthesis of a protein (or proteins) is involved in the phototransduction pathway of the circadian clock in Neurospora.

MeSH Terms (6)

Bacterial Proteins Circadian Rhythm Cycloheximide Leucine Light Neurospora

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