Benjamin Spiller
Last active: 4/10/2019

Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.

Germane KL, Ohi R, Goldberg MB, Spiller BW
Biochemistry. 2008 47 (39): 10241-3

PMID: 18763811 · PMCID: PMC4096815 · DOI:10.1021/bi801533k

VirA, an essential virulence factor in Shigella disease pathogenesis, is involved in the uptake, motility, and cell-to-cell spread of Shigella organisms within the human host. These functions have been attributed to a VirA protease activity and a mechanism of microtubule destruction via tubulin degradation [Yoshida, S., et al. (2006) Science 314, 985-989]. We report functional and crystallographic data indicating a novel VirA structure that lacks these activities but highlights the homology to the EspG virulence factor of pathogenic Escherichia coli.

MeSH Terms (11)

Bacterial Proteins Dysentery, Bacillary Escherichia coli Proteins Humans Microtubules Models, Molecular Papain Protein Conformation Shigella Tubulin Virulence Factors

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