Kevin Osteen
Last active: 2/19/2015

Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.

Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A
Reprod Sci. 2012 19 (6): 572-9

PMID: 22267540 · PMCID: PMC3439122 · DOI:10.1177/1933719111430998

Statins are potent inhibitors of the endogenous mevalonate pathway. Besides inhibiting cholesterol biosynthesis, statins may also demonstrate anti-inflammatory properties. Inflammation is implicated in the attachment and invasion of endometrial cells to the peritoneal surface and growth of ectopic endometrium by inducing proliferation and angiogenesis. In this study, the effect of statins on monocyte chemotactic protein 1 (MCP-1) expression in endometriotic implants in nude mouse model and in cultured endometriotic cells was evaluated. In mouse model, simvastatin decreased MCP-1 expression in a dose-dependent manner in endometriotic implants (P < .05). Similarly, both simvastatin and mevastatin revealed a dose-dependent inhibition of MCP-1 production in cultured endometriotic cells (P < .01). This inhibitory effect of the statins on MCP-1 production was reversed by the downstream substrates of the mevalonate pathway. Moreover, statins decreased MCP-1 messenger RNA expression in cultured endometriotic cells (P < .05). In conclusion, statins exert anti-inflammatory effect in endometriotic cells and could provide a potential treatment of endometriosis in the future.

MeSH Terms (18)

Adolescent Adult Animals Cells, Cultured Chemokine CCL2 Disease Models, Animal Endometriosis Endometrium Female Gene Expression Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Mice Mice, Nude Middle Aged RNA, Messenger Simvastatin Transplantation, Heterologous

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