Kevin Osteen
Last active: 2/19/2015

Dioxin and endometrial progesterone resistance.

Bruner-Tran KL, Ding T, Osteen KG
Semin Reprod Med. 2010 28 (1): 59-68

PMID: 20104429 · PMCID: PMC2875884 · DOI:10.1055/s-0029-1242995

Development of endometriosis likely requires multiple, interactive mechanisms involving both the endocrine and immune systems. Environmental toxicants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are of particular interest as potential contributory agents in the development of this disease because they can disrupt both systems. Nevertheless, defining the potential role that environmental exposure to TCDD plays in the development of endometriosis requires a better understanding of how this toxicant affects the biological processes that promote the disease. Although the disease mechanism(s) responsible for progesterone resistance in the endometrium of endometriosis patients remains speculative, our studies indicate that developmental exposure of mice to TCDD leads to a progesterone-resistant phenotype in adult animals that can persist for several generations. These studies and others underscore the importance of developing a greater understanding of the mechanisms of TCDD action that relate to reproductive disorders such as endometriosis.

MeSH Terms (11)

Animals Endometriosis Endometrium Environmental Exposure Environmental Pollutants Female Humans Mice Polychlorinated Dibenzodioxins Progesterone Receptors, Progesterone

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