Joey Barnett
Last active: 4/15/2019

The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.

Jacobson R, Mignemi N, Rose K, O'Rear L, Sarilla S, Hamm HE, Barnett JV, Verhamme IM, Schoenecker J
Thromb Res. 2014 134 (6): 1350-7

PMID: 25307422 · PMCID: PMC4337957 · DOI:10.1016/j.thromres.2014.09.038

MeSH Terms (9)

Anticoagulants Antithrombin III Blood Coagulation Dose-Response Relationship, Drug Heparin Humans Hyperglycemia Protein Binding Pyruvaldehyde

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