Warren Taylor
Last active: 3/3/2020

Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.

Chang CC, Yu SC, McQuoid DR, Messer DF, Taylor WD, Singh K, Boyd BD, Krishnan KR, MacFall JR, Steffens DC, Payne ME
Psychiatry Res. 2011 193 (1): 1-6

PMID: 21596532 · PMCID: PMC3105213 · DOI:10.1016/j.pscychresns.2011.01.003

Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex (dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for dlPFC volume differences between older depressed and non-depressed individuals. Eighty-eight subjects meeting DSM IV criteria for major depressive disorder and thirty-five control subjects completed clinical evaluations and cranial 3T magnetic resonance imaging. After tissue types were identified using an automated segmentation process, the dlPFC was measured in both hemispheres using manual delineation based on anatomical landmarks. Depressed subjects had significantly lower gray matter in the left and right dorsolateral prefrontal cortex (standardized to cerebral parenchyma) after controlling for age and sex. Our study confirmed the reduction of dorsolateral prefrontal cortex in elderly depressed subjects, especially in the gray matter. These regional abnormalities may be associated with psychopathological changes in late-life depression.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

MeSH Terms (13)

Aged Aged, 80 and over Depression Female Humans Image Processing, Computer-Assisted Linear Models Magnetic Resonance Imaging Male Mental Status Schedule Middle Aged Prefrontal Cortex Reproducibility of Results

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