Paul Newhouse
Last active: 3/3/2020

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Albert KM, Newhouse PA
Annu Rev Clin Psychol. 2019 15: 399-423

PMID: 30786242 · DOI:10.1146/annurev-clinpsy-050718-095557

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. We propose a model of estrogen effects on multiple brain systems that interface with stress-related emotional and cognitive processes implicated in MDD and discuss possible mechanisms through which reproductive events and changes in estrogen may contribute to MDD risk in women with other concurrent risk factors.

MeSH Terms (10)

Attention Brain Cognitive Dysfunction Depressive Disorder, Major Emotional Regulation Estrogens Female Humans Nerve Net Stress, Psychological

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