Brett Byram
Last active: 4/3/2018

Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure.

Rotemberg V, Byram B, Palmeri M, Wang M, Nightingale K
J Biomech. 2013 46 (11): 1875-81

PMID: 23726184 · PMCID: PMC3812539 · DOI:10.1016/j.jbiomech.2013.04.027

Elevated hepatic venous pressure is the primary source of complications in advancing liver disease. Ultrasound imaging is ideal for potential noninvasive hepatic pressure measurements as it is widely used for liver imaging. Specifically, ultrasound based stiffness measures may be useful for clinically monitoring pressure, but the mechanism by which liver stiffness increases with hepatic pressure has not been well characterized. This study is designed to elucidate the nonlinear properties of the liver during pressurization by measuring both hepatic shear wave speed (SWS) and strain with increasing pressure. Tissue deformation during hepatic pressurization was tracked in 8 canine livers using successively acquired 3-D B-mode volumes and compared with concurrently measured SWS. When portal venous pressure was increased from clinically normal (0-5mmHg) to pressures representing highly diseased states at 20mmHg, the liver was observed to expand with axial strain measures up to 10%. At the same time, SWS estimates were observed to increase from 1.5-2m/s at 0-5mmHg (baseline) to 3.25-3.5m/s at 20mmHg.

Copyright © 2013 Elsevier Ltd. All rights reserved.

MeSH Terms (11)

Animals Biomechanical Phenomena Dogs Liver Liver Circulation Models, Cardiovascular Nonlinear Dynamics Portal Pressure Portal Vein Ultrasonography Vascular Stiffness

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