Claus Schneider
Last active: 4/5/2016

Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla.

Schneider C, Manier ML, Hachey DL, Brash AR
Lipids. 2002 37 (2): 217-21

PMID: 11908914 · DOI:10.1007/s11745-002-0883-5

15R-Prostaglandin E2 (PGE2) methyl ester 15-acetate (1) was isolated from the R-variety of the Caribbean sea whip coral Plexaura homomalla collected in the Florida Keys. It was present in coral samples from separate collections in 2-10% of the abundance of the major prostaglandin component, PGA2 methyl ester 15-acetate. The structure of 1 was assigned based on one- and two-dimensional 1H NMR, HPLC, and LC-MS analyses. A sample of the S-variety of P. homomalla was found to contain a similar abundance of the corresponding 15S product, prostaglandin E2 methyl ester 15-acetate. The significance of PGE acetylation is discussed in relation to the proposed mechanism of PGA synthesis in the coral.

MeSH Terms (8)

Acetates Acetylation Animals Chromatography, High Pressure Liquid Cnidaria Dinoprostone Mass Spectrometry Nuclear Magnetic Resonance, Biomolecular

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