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Charles Sanders
Faculty Member
Last active: 3/3/2020

Cholesterol as a co-solvent and a ligand for membrane proteins.

Song Y, Kenworthy AK, Sanders CR
Protein Sci. 2014 23 (1): 1-22

PMID: 24155031 · PMCID: PMC3892294 · DOI:10.1002/pro.2385

As of mid 2013 a Medline search on "cholesterol" yielded over 200,000 hits, reflecting the prominence of this lipid in numerous aspects of animal cell biology and physiology under conditions of health and disease. Aberrations in cholesterol homeostasis underlie both a number of rare genetic disorders and contribute to common sporadic and complex disorders including heart disease, stroke, type II diabetes, and Alzheimer's disease. The corresponding author of this review and his lab stumbled only recently into the sprawling area of cholesterol research when they discovered that the amyloid precursor protein (APP) binds cholesterol, a topic covered by the Hans Neurath Award lecture at the 2013 Protein Society Meeting. Here, we first provide a brief overview of cholesterol-protein interactions and then offer our perspective on how and why binding of cholesterol to APP and its C99 domain (β-CTF) promotes the amyloidogenic pathway, which is closely related to the etiology of Alzheimer's disease.

© 2013 The Protein Society.

MeSH Terms (13)

Alzheimer Disease Amyloid beta-Protein Precursor Animals Binding Sites Cholesterol Humans Ligands Membrane Proteins Models, Molecular Peptide Fragments Protein Binding Protein Conformation Protein Structure, Secondary

Connections (2)

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