Henry Ong
Post-Doctoral Fellow
Last active: 4/25/2016

Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging.

Anumula S, Magland J, Wehrli SL, Zhang H, Ong H, Song HK, Wehrli FW
Magn Reson Med. 2006 56 (5): 946-52

PMID: 17041893 · DOI:10.1002/mrm.21050

In osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid-state (31)P magnetic resonance imaging (SS-MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro-CT (micro-CT) and (31)P solution NMR. 3D images of 277 microm isotropic voxel size were obtained in 1.7 hr with SNR approximately 9. Mineral content was lower in the HY relative to the NO group (SS-MRI: 9.48 +/- 0.4 vs. 11.15 +/- 0.31 phosphorus wet wt %, P < 0.0001; micro-CT: 1114.6 +/- 28.3 vs. 1175.7 +/- 23.5 mg mineral/cm(3); P = 0.003). T(1) was shorter in the HY group (47.2 +/- 3.5 vs. 54.1 +/- 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole-dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals.

(c) 2006 Wiley-Liss, Inc.

MeSH Terms (17)

Anatomy, Cross-Sectional Animals Biomarkers Bone Density Feasibility Studies Femur Humans Imaging, Three-Dimensional Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Osteomalacia Phosphorus Phosphorus Radioisotopes Rabbits Reproducibility of Results Sensitivity and Specificity Tibia

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