Oxidant stress in HIV-infected women from the Women's Interagency HIV Study.

Glesby MJ, Hoover DR, Raiszadeh F, Lee I, Shi Q, Milne G, Sanchez SC, Gao W, Kaplan RC, Morrow JD, Anastos K
Antivir Ther. 2009 14 (6): 763-9

PMID: 19812438 · PMCID: PMC2760028 · DOI:10.3851/IMP1290

BACKGROUND - Oxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F(2)-isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women.

METHODS - We measured plasma F(2)-isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women's Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression.

RESULTS - In multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F(2)-isoprostane concentration (all P<0.005). There was a trend for an inverse association between log F(2)-isoprostane and CD4(+) T-cell percentage (P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F(2)-isoprostane concentration.

CONCLUSIONS - In this cross-sectional study of HIV-infected women, plasma F(2)-isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.

MeSH Terms (12)

Adult Atherosclerosis Cross-Sectional Studies F2-Isoprostanes Female HIV Infections Homocysteine Humans Middle Aged Oxidants Oxidative Stress Risk Factors

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