Michael Waterman
Faculty Member
Last active: 2/12/2015

Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding.

Fan YS, Sasi R, Lee C, Winter JS, Waterman MR, Lin CC
Genomics. 1992 14 (4): 1110-1

PMID: 1478654 · DOI:10.1016/s0888-7543(05)80140-5

The gene for human P450(17 alpha) (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17 alpha-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

MeSH Terms (9)

Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 10 Cytochrome P-450 Enzyme System DNA Humans In Situ Hybridization, Fluorescence Karyotyping Steroid 17-alpha-Hydroxylase

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