Michael Waterman
Faculty Member
Last active: 2/12/2015

Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.

Friggeri L, Hargrove TY, Rachakonda G, Williams AD, Wawrzak Z, Di Santo R, De Vita D, Waterman MR, Tortorella S, Villalta F, Lepesheva GI
J Med Chem. 2014 57 (15): 6704-17

PMID: 25033013 · PMCID: PMC4136671 · DOI:10.1021/jm500739f

MeSH Terms (12)

14-alpha Demethylase Inhibitors Carbamates Crystallography, X-Ray Drug Design Imidazoles Models, Molecular Protein Binding Protein Conformation Stereoisomerism Sterol 14-Demethylase Trypanocidal Agents Trypanosoma cruzi

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