Michael Waterman
Faculty Member
Last active: 2/12/2015

Cytochromes p450: roles in diseases.

Pikuleva IA, Waterman MR
J Biol Chem. 2013 288 (24): 17091-8

PMID: 23632021 · PMCID: PMC3682515 · DOI:10.1074/jbc.R112.431916

The cytochrome P450 superfamily consists of a large number of heme-containing monooxygenases. Many human P450s metabolize drugs used to treat human diseases. Others are necessary for synthesis of endogenous compounds essential for human physiology. In some instances, alterations in specific P450s affect the biological processes that they mediate and lead to a disease. In this minireview, we describe medically significant human P450s (from families 2, 4, 7, 11, 17, 19, 21, 24, 27, 46, and 51) and the diseases associated with these P450s.

MeSH Terms (8)

Animals Cholecalciferol Cytochrome P-450 Enzyme System Eicosanoids Humans Metabolic Diseases Mutation Steroids

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