Ned Porter
Faculty Member
Last active: 5/29/2014

Measuring electrophile stress.

Tallman KA, Vila A, Porter NA, Marnett LJ
Curr Protoc Toxicol. 2009 Chapter 17: Unit17.11

PMID: 23045010 · DOI:10.1002/0471140856.tx1711s40

Polyunsaturated fatty acids are primary targets during oxidative stress. Diffusible electrophilic α,β-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling and modify gene expression pathways. We describe a global strategy for identifying the protein targets of HNE modification. A similar approach can be used for any electrophiles derived from an oxidized lipid.

MeSH Terms (7)

Aldehydes Click Chemistry Cross-Linking Reagents Lipid Metabolism Lipid Peroxidation Oxidative Stress Proteins

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