Ned Porter
Faculty Member
Last active: 5/29/2014

Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation.

Schneider C, Porter NA, Brash AR
J Biol Chem. 2008 283 (23): 15539-43

PMID: 18285327 · PMCID: PMC2414272 · DOI:10.1074/jbc.R800001200

Although investigation of the toxicological and physiological actions of alpha/beta-unsaturated 4-hydroxyalkenals has made great progress over the last 2 decades, understanding of the chemical mechanism of formation of 4-hydroxynonenal and related aldehydes has advanced much less. The aim of this review is to discuss mechanistic evidence for these non-enzymatic routes, especially of the underappreciated intermolecular pathways that involve dimerized and oligomerized fatty acid derivatives as key intermediates. These cross-molecular reactions of fatty acid peroxyls have also important implications for understanding of the basic initiation and propagation steps during lipid peroxidation and the nature of the products that arise.

MeSH Terms (6)

Aldehydes Animals Dimerization Fatty Acids Humans Lipid Peroxidation

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