Ned Porter
Faculty Member
Last active: 5/29/2014

Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein.

Kim HY, Pratt DA, Seal JR, Wijtmans M, Porter NA
J Med Chem. 2005 48 (22): 6787-9

PMID: 16250637 · DOI:10.1021/jm0507173

Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

MeSH Terms (8)

alpha-Tocopherol Antioxidants Humans Lipid Peroxidation Lipoproteins, LDL Pyridines Structure-Activity Relationship Tryptophan

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