Yajun Yi
Faculty Member
Last active: 3/24/2014

SPARCL1 suppresses metastasis in prostate cancer.

Xiang Y, Qiu Q, Jiang M, Jin R, Lehmann BD, Strand DW, Jovanovic B, DeGraff DJ, Zheng Y, Yousif DA, Simmons CQ, Case TC, Yi J, Cates JM, Virostko J, He X, Jin X, Hayward SW, Matusik RJ, George AL, Yi Y
Mol Oncol. 2013 7 (6): 1019-30

PMID: 23916135 · PMCID: PMC3838491 · DOI:10.1016/j.molonc.2013.07.008

PURPOSE - Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level.

EXPERIMENTAL DESIGN - Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used in vitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis in vivo.

RESULTS - SPARCL1 expression did not inhibit tumor cell proliferation in vitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models.

CONCLUSIONS - We present the first in vivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.

Copyright © 2013 Federation of European Biochemical Societies. All rights reserved.

MeSH Terms (15)

Animals Calcium-Binding Proteins Cell Line, Tumor Extracellular Matrix Proteins Gene Expression Regulation, Neoplastic Heterografts Humans Male Meta-Analysis as Topic Mice Mice, SCID Neoplasm Metastasis Neoplasm Transplantation Prostatic Neoplasms Tumor Suppressor Proteins

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