Gong Yang
Faculty Member
Last active: 4/27/2017

Pre-diagnostic cruciferous vegetables intake and lung cancer survival among Chinese women.

Wu QJ, Yang G, Zheng W, Li HL, Gao J, Wang J, Gao YT, Shu XO, Xiang YB
Sci Rep. 2015 5: 10306

PMID: 25988580 · PMCID: PMC4650798 · DOI:10.1038/srep10306

No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake was assessed for all SWHS participants at enrollment and reassessed 2-3 years later. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for potential confounders. Of the 547 lung cancer patients, 412 patients died during the follow-up. A total of 393 (95.4%) deaths from lung cancer were documented with median survival time of 10.3 months (interquartile range, 3.6-21.1 months). High cruciferous vegetables intake was significantly associated with improved lung cancer-specific survival after adjusting for all nonclinical prognostic factors (n = 547, HR = 0.69; 95%CI = 0.49-0.95; P trend = 0.02) for the highest versus lowest quartile. A slightly stronger association of cruciferous vegetables intake with lung cancer-specific survival was observed in analyses restricted to patients with known clinical prognostic factors (n = 331, HR = 0.63; 95%CI = 0.41-0.97; P trend = 0.03) or never smokers (n = 308, HR = 0.58; 95%CI = 0.37-0.91; P trend = 0.02). In conclusion, pre-diagnostic cruciferous vegetables intake is associated with better survival of lung cancer in Chinese women.

MeSH Terms (14)

Adult Aged China Cohort Studies Diet Female Humans Life Style Lung Neoplasms Middle Aged Prospective Studies Risk Factors Surveys and Questionnaires Vegetables

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