Gong Yang
Faculty Member
Last active: 4/27/2017

Polycyclic aromatic hydrocarbons and risk of gastric cancer in the Shanghai Women's Health Study.

Liao LM, Hofmann JN, Kamangar F, Strickland PT, Ji BT, Yang G, Li HL, Rothman N, Zheng W, Chow WH, Gao YT, Shu XO
Int J Mol Epidemiol Genet. 2014 5 (3): 140-4

PMID: 25379133 · PMCID: PMC4214261

PURPOSE - Polycyclic aromatic hydrocarbons (PAHs) are byproducts of incomplete combustion of organic materials. Sources include tobacco smoke, charbroiled meat, and air pollution. Indirect evidence suggests that PAHs may be associated with carcinogenesis, but the association with gastric cancer is unclear.

METHODS - Using a nested case-control study design, we examined prediagnostic urinary concentrations of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in 153 gastric cancer cases and 306 matched controls within the Shanghai Women's Health Study. Conditional logistic regression adjusted for potential risk factors was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).

RESULTS - Urinary 1-OHPG concentrations were slightly higher among cases than controls, with medians of 0.29 μmol/mol Cr (interquartile range, 0.16-0.48) and 0.24 μmol/mol Cr (interquartile range, 0.12-0.45), respectively. Increasing concentrations of 1-OHPG appeared to be associated with elevated risk of gastric cancer, but not within the highest category of 1-OHPG (Q4 vs Q1: OR = 1.4; 95% CI = 0.8-2.5).

CONCLUSIONS - Our findings suggest that higher concentrations of 1-OHPG are related to gastric cancer risk, but no clear dose-response relationship was observed.

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