Gong Yang
Faculty Member
Last active: 4/27/2017

Pre-existing type 2 diabetes and risk of lung cancer: a report from two prospective cohort studies of 133 024 Chinese adults in urban Shanghai.

Yang WS, Yang Y, Yang G, Chow WH, Li HL, Gao YT, Ji BT, Rothman N, Zheng W, Shu XO, Xiang YB
BMJ Open. 2014 4 (7): e004875

PMID: 24993754 · PMCID: PMC4091264 · DOI:10.1136/bmjopen-2014-004875

OBJECTIVES - Observational studies of type 2 diabetes (T2D) and lung cancer risk are limited and controversial. We thus examined the association between T2D and risk of incident lung cancer using a cohort design.

SETTING - Data from two ongoing population-based cohorts (the Shanghai Men's Health Study, SMHS, 2002-2006 and the Shanghai Women's Health Study, SWHS, 1996-2000) were used. Cox proportional-hazards regression models with T2D as a time-varying exposure were modelled to estimate HRs and 95% CIs.

PARTICIPANTS - The study population included 61 491 male participants aged 40-74 years from SMHS and 74 941 female participants aged 40-70 years from SWHS.

OUTCOME MEASURE - Lung cancer cases were identified through annual record linkage to the Shanghai Cancer Registry and Shanghai Municipal Registry of Vital Statistics, and were further verified through home visits and a review of medical charts by clinical and/or pathological experts. Outcome data until 31 December 2010 for men and women were used for the present analysis.

RESULTS - After a median follow-up of 6.3 years for SMHS and 12.2 years for SWHS, incident lung cancer cases were detected in 492 men and 525 women. A null association between T2D and lung cancer risk was observed in men (HR=0.87, 95% CI 0.62 to 1.21) and women (HR=0.92, 95% CI 0.69 to 1.24) after adjustments for potential confounders. Similar results were observed among never smokers.

CONCLUSIONS - There is little evidence that pre-existing T2D may influence the incidence of lung cancer.

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MeSH Terms (14)

Adult Aged Asian Continental Ancestry Group China Cohort Studies Diabetes Mellitus, Type 2 Female Humans Lung Neoplasms Male Middle Aged Prospective Studies Risk Assessment Urban Health

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