Gong Yang
Faculty Member
Last active: 4/27/2017

Nightshift work job exposure matrices and urinary 6-sulfatoxymelatonin levels among healthy Chinese women.

Ji BT, Gao YT, Shu XO, Yang G, Yu K, Xue SZ, Li HL, Liao LM, Blair A, Rothman N, Zheng W, Chow WH
Scand J Work Environ Health. 2012 38 (6): 553-9

PMID: 22975884 · PMCID: PMC4290163 · DOI:10.5271/sjweh.3322

OBJECTIVE - Six-sulfatoxymelatonin (aMT6s) is a primary urinary metabolite of melatonin. We examined the association between aMT6s levels and shift work estimated by a job exposure matrix (JEM) among healthy participants of the Shanghai Women's Health Study.

METHODS - Creatinine-adjusted aMT6s levels were measured in the urine samples of 300 women and related to JEM shift work categories.

RESULTS - Adjusted geometric means of aMT6s levels from urine samples collected before 08:00 hours were lower among persons holding nighttime shift work jobs. The adjusted aMT6s levels (ng/mg creatinine) were 8.36 [95% confidence intervals (95% CI) 4.47-15.6], 6.37 (95% CI 3.53-11.5), 6.20 (95% CI 3.33-11.5), 3.81 (95% CI 2.02-7.19), and 3.70 (95% CI 1.92-7.11) from the lowest (never held a shift work job) to the highest (current job likely involved all-night shift work) shift work JEM scores (P=0.05).

CONCLUSION - Our results indicate that nightshift work JEM scores were significantly and inversely associated with aMT6s levels in early morning spot urine samples collected between 07:00-08:00 hours.

MeSH Terms (9)

Adult Aged China Female Humans Melatonin Middle Aged Reference Values Work Schedule Tolerance

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