Keith Wilson
Faculty Member
Last active: 8/13/2019

The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice.

Garay J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, Zabaleta J
Cancer Lett. 2016 371 (1): 90-8

PMID: 26639196 · PMCID: PMC4714604 · DOI:10.1016/j.canlet.2015.10.037

Infection with Helicobacter pylori (H. pylori) leads to inflammatory events that can promote gastric cancer development. Immune cells transition from the circulation into the infected mucosa through the interaction of their receptors and ligands in the endothelial compartment. CD44 expression is increased in advanced gastric lesions. However, the association of this molecule with the progression of these lesions over time has not been investigated. In addition, there is a lack of understanding of the CD44-dependent cellular processes that lead to gastritis, and possibly to gastric cancer. Here we studied H. pylori-positive subjects with gastric lesions that ranged from multifocal atrophic gastritis to dysplasia to determine gene expression changes associated with disease progression over a period of 6 years. We report that CD44 expression is significantly increased in individuals whose gastric lesions progressed along the gastric precancerous cascade. We also show that CD44-/- mice develop less severe and less extensive H. pylori-induced metaplasia, and show fewer infiltrating Gr1+ cells compared to wild type mice. We present data suggesting that CD44 is associated with disease progression. Mechanisms associated with these effects include induction of interferon gamma responses.

Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

MeSH Terms (22)

Animals Antigens, Ly Cells, Cultured Chemotaxis, Leukocyte Disease Models, Animal Disease Progression Female Gastric Mucosa Gastritis, Atrophic Helicobacter Infections Helicobacter pylori Humans Hyaluronan Receptors Interferon-gamma Macrophages, Peritoneal Mice, Knockout Neutrophil Infiltration Neutrophils Precancerous Conditions Signal Transduction Stomach Neoplasms Time Factors

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