Keith Wilson
Faculty Member
Last active: 12/19/2020

Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise.

Gobert AP, Wilson KT
Free Radic Biol Med. 2017 105: 16-27

PMID: 27682363 · PMCID: PMC5366100 · DOI:10.1016/j.freeradbiomed.2016.09.024

Helicobacter pylori is a Gram-negative bacterium that specifically colonizes the gastric ecological niche. During the infectious process, which results in diseases ranging from chronic gastritis to gastric cancer, the host response is characterized by the activation of the innate immunity of gastric epithelial cells and macrophages. These cells thus produce effector molecules such as reactive oxygen species (ROS) to counteract the infection. The generation of ROS in response to H. pylori involves two canonical pathways: 1) the NADPH-dependent reduction of molecular oxygen to generate O, which can dismute to generate ROS; and 2) the back-conversion of the polyamine spermine into spermidine through the enzyme spermine oxidase, leading to HO production. Although these products have the potential to affect the survival of bacteria, H. pylori has acquired numerous strategies to counteract their deleterious effects. Nonetheless, ROS-mediated oxidative DNA damage and mutations may participate in the adaptation of H. pylori to its ecological niche. Lastly, ROS have been shown to play a major role in the development of the inflammation and carcinogenesis. It is the purpose of this review to summarize the literature about the production of ROS during H. pylori infection and their role in this infectious gastric disease.

Published by Elsevier Inc.

MeSH Terms (11)

Animals DNA Damage Helicobacter Infections Helicobacter pylori Host-Pathogen Interactions Humans NADP NADPH Oxidases Oxidative Stress Polyamines Reactive Oxygen Species

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