Alex Waterson
Faculty Member
Last active: 3/21/2014

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Burns MC, Sun Q, Daniels RN, Camper D, Kennedy JP, Phan J, Olejniczak ET, Lee T, Waterson AG, Rossanese OW, Fesik SW
Proc Natl Acad Sci U S A. 2014 111 (9): 3401-6

PMID: 24550516 · PMCID: PMC3948241 · DOI:10.1073/pnas.1315798111

MeSH Terms (17)

Chromatography, Liquid Chromatography, Thin Layer Crystallography, X-Ray Fluorescence Polarization HeLa Cells Humans Indoles Ligands Magnetic Resonance Spectroscopy Mass Spectrometry Models, Molecular Molecular Structure Multiprotein Complexes Piperidines Protein Conformation Proto-Oncogene Proteins p21(ras) SOS1 Protein

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