Alex Waterson
Faculty Member
Last active: 3/21/2014

Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A.

Frank AO, Vangamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D, Olejniczak ET, Waterson AG, Rossanese OW, Chazin WJ, Fesik SW
J Med Chem. 2014 57 (6): 2455-61

PMID: 24491171 · PMCID: PMC3969094 · DOI:10.1021/jm401730y

MeSH Terms (19)

Alanine Amino Acid Sequence Cell Line Crystallization Crystallography, X-Ray DNA, Single-Stranded Drug Discovery Electrophoretic Mobility Shift Assay Fluorescence Polarization Magnetic Resonance Spectroscopy Microscopy, Fluorescence Models, Molecular Molecular Sequence Data Penetrance Peptides Protein Conformation Replication Protein A Structure-Activity Relationship Tumor Suppressor Protein p53

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