Alex Waterson
Faculty Member
Last active: 3/21/2014

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E
Nat Chem Biol. 2010 6 (11): 829-36

PMID: 20890287 · PMCID: PMC3681608 · DOI:10.1038/nchembio.453

MeSH Terms (23)

Adaptor Proteins, Signal Transducing Adenomatous Polyposis Coli Animals Axin Protein beta Catenin Casein Kinase I Casein Kinase Ialpha Cell Extracts Cell Line, Tumor Cell Proliferation Colonic Neoplasms Dose-Response Relationship, Drug Enzyme Activation Enzyme Inhibitors Humans Intracellular Signaling Peptides and Proteins Oocytes Pyrvinium Compounds Repressor Proteins Signal Transduction Wnt Proteins Xenopus laevis Xenopus Proteins

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