Douglas Sawyer
Faculty Member
Last active: 7/21/2014

Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure.

Henry-Okafor Q, Collins SP, Jenkins CA, Miller KF, Maron DJ, Naftilan AJ, Weintraub N, Fermann GJ, McPherson J, Menon S, Sawyer DB, Storrow AB
Open Biomark J. 2012 5: 9-15

PMID: 24058387 · PMCID: PMC3777695 · DOI:10.2174/1875318301205010009

OBJECTIVES - We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).

METHODS - We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.

RESULTS - Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.

CONCLUSION - Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

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