Joe Putnam
Faculty Member
Last active: 3/27/2014

Surgical resection of non-small cell carcinoma after treatment for small cell carcinoma.

Smythe WR, Estrera AL, Swisher SG, Merriman KW, Walsh GL, Putnam JB, Vaporciyan AA, Roth JA
Ann Thorac Surg. 2001 71 (3): 962-6

PMID: 11269481 · DOI:10.1016/s0003-4975(00)02459-0

BACKGROUND - Development of non-small cell lung carcinoma (NSCLC) in patients previously treated for small cell carcinoma (SCLC/NSCLC) is well described; however, little is known about clinical outcome.

METHODS - A single-institution 20-year review was performed. Patient characteristics and survival for SCLC/ NSCLC patients were compared with those for control patients matched for stage, resection, and previous malignancy.

RESULTS - One thousand four hundred four patients with small cell carcinoma were identified, and 29 underwent therapy for metachronous NSCLC: 11 of 29 patients underwent surgical resection, 10 of these 11 (90%) were stage I. Compared with surgically treated stage I NSCLC patients, SCLC/NSCLC patients were more likely to have squamous histology (70% versus 35%, p = 0.026); and subanatomic resection (90% versus 17.4%, p < 0.0005). The SCLC/NSCLC patients had significantly poorer survival when compared with stage I NSCLC patients undergoing any resection (24.53 versus 74.43 months, p = 0.003) and stage I NSCLC patients receiving wedge resection (24.53 versus 58.39 months, p = 0.006). Survival was similar to NSCLC patients with a history of previous treated extrathoracic solid malignancy.

CONCLUSIONS - Surgical resection for SCLC/NSCLC patients is feasible, but poorer prognosis is noted when compared with stage-matched control patients. Surgical candidates should be carefully chosen, and alternative local control modalities considered.

MeSH Terms (10)

Carcinoma, Non-Small-Cell Lung Carcinoma, Small Cell Female Humans Lung Neoplasms Male Middle Aged Neoplasms, Second Primary Survival Rate Treatment Outcome

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