McClure R, Ong H, Janve V, Barton S, Zhu M, Li B, Dawes M, Jerome WG, Anderson A, Massion P, Gore JC, Pham W
J Alzheimers Dis. 2017 55 (2)
· PMCID: PMC5848215
We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.
MeSH Terms (22)Administration, Inhalation Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal Cognition Disorders Curcumin Dendritic Spines Disease Models, Animal Hippocampus Humans Maze Learning Memory, Short-Term Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission Mutation Neurons Presenilin-1