Wellington Pham
Faculty Member
Last active: 4/2/2019

Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.

McClure R, Ong H, Janve V, Barton S, Zhu M, Li B, Dawes M, Jerome WG, Anderson A, Massion P, Gore JC, Pham W
J Alzheimers Dis. 2017 55 (2): 797-811

PMID: 27802223 · PMCID: PMC5848215 · DOI:10.3233/JAD-160289

We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.

MeSH Terms (22)

Administration, Inhalation Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal Cognition Disorders Curcumin Dendritic Spines Disease Models, Animal Hippocampus Humans Maze Learning Memory, Short-Term Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission Mutation Neurons Presenilin-1

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