Pierre Massion
Faculty Member
Last active: 1/11/2018

Advances in proteomic strategies toward the early detection of lung cancer.

Hassanein M, Rahman JS, Chaurand P, Massion PP
Proc Am Thorac Soc. 2011 8 (2): 183-8

PMID: 21543799 · PMCID: PMC3131837 · DOI:10.1513/pats.201012-069MS

Since the advent of the new proteomics era more than a decade ago, large-scale studies of protein profiling have been exploited to identify the distinctive molecular signatures in a wide array of biological systems spanning areas of basic biological research, various disease states, and biomarker discovery directed toward therapeutic applications. Recent advances in protein separation and identification techniques have significantly improved proteomics approaches, leading to enhancement of the depth and breadth of proteome coverage. Proteomic signatures specific for invasive lung cancer and preinvasive lesions have begun to emerge. In this review we provide a critical assessment of the state of recent advances in proteomic approaches and the biological lessons they have yielded, with specific emphasis on the discovery of biomarker signatures for the early detection of lung cancer.

MeSH Terms (9)

Biomarkers, Tumor Disease Progression Early Detection of Cancer Humans Lung Neoplasms Precancerous Conditions Proteomics Risk Assessment Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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