Pierre Massion
Faculty Member
Last active: 1/11/2018

Evolving concepts in lung carcinogenesis.

Gomperts BN, Spira A, Massion PP, Walser TC, Wistuba II, Minna JD, Dubinett SM
Semin Respir Crit Care Med. 2011 32 (1): 32-43

PMID: 21500122 · PMCID: PMC3423907 · DOI:10.1055/s-0031-1272867

Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the "field of cancerization," and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer.

© Thieme Medical Publishers.

MeSH Terms (14)

Animals Anticarcinogenic Agents Epigenesis, Genetic Epigenomics Gene Expression Profiling Genomics Genomics High-Throughput Nucleotide Sequencing Humans Inflammation Lung Neoplasms Mutation Neoplastic Stem Cells Proteomics

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