H. Manning
Faculty Member
Last active: 3/22/2018

Intracardiac Metastases Detected by 18F-FSPG PET/CT.

Magarik MA, Walker RC, Gilbert J, Manning HC, Massion PP
Clin Nucl Med. 2018 43 (1): 28-30

PMID: 29076915 · PMCID: PMC5716866 · DOI:10.1097/RLU.0000000000001883

PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-F-fluoropropyl)-L-glutamate (F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of F-FSPG PET/CT imaging.

MeSH Terms (8)

Carcinoma, Non-Small-Cell Lung Female Glutamates Heart Neoplasms Humans Lung Neoplasms Middle Aged Positron Emission Tomography Computed Tomography

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