Ethan Lee
Faculty Member
Last active: 7/6/2018

Characterization of a null allele in .

Neitzel LR, Broadus MR, Zhang N, Sawyer L, Wallace HA, Merkle JA, Jodoin JN, Sitaram P, Crispi EE, Rork W, Lee LA, Pan D, Gould KL, Page-McCaw A, Lee E
Biol Open. 2018 7 (7)

PMID: 29945873 · PMCID: PMC6078348 · DOI:10.1242/bio.035394

Cdc14 is an evolutionarily conserved serine/threonine phosphatase. Originally identified in as a cell cycle regulator, its role in other eukaryotic organisms remains unclear. In , Cdc14 is encoded by a single gene, thus facilitating its study. We found that Cdc14 expression is highest in the testis of adult flies and that null flies are viable. null female and male flies do not display altered fertility. null males, however, exhibit decreased sperm competitiveness. Previous studies have shown that Cdc14 plays a role in ciliogenesis during zebrafish development. In Drosophila, sensory neurons are ciliated. We found that the Drosophila null mutants have defects in chemosensation and mechanosensation as indicated by decreased avoidance of repellant substances and decreased response to touch. In addition, we show that null mutants have defects in lipid metabolism and resistance to starvation. These studies highlight the diversity of Cdc14 function in eukaryotes despite its structural conservation.

© 2018. Published by The Company of Biologists Ltd.

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