Debra Friedman
Faculty Member
Last active: 2/12/2015

Adverse behavioral effects in individuals with mental retardation and mood disorders treated with carbamazepine.

Friedman DL, Kastner T, Plummer AT, Ruiz MQ, Henning D
Am J Ment Retard. 1992 96 (5): 541-6

PMID: 1562312

The incidence of carbamazepine-associated behavioral side effects in 65 individuals with mental retardation and additional seizure and/or psychiatric or behavioral disorders was evaluated. We identified 6 patients (9.2%) who experienced medication side effects, ranging from irritability to mania. Four of the 20 patients (20%) who received carbamazepine purely for treatment of a behavioral or psychiatric disorder experienced medication side effects, whereas none of the 21 patients treated for an isolated seizure disorder experienced similar effects. This difference was statistically significant, p less than .05. The incidence of behavioral side effects of medication was not associated with age, sex, or serum carbamazepine level. The chemical structure and mechanism of carbamazepine use in various disease processes were discussed.

MeSH Terms (15)

Adolescent Adult Aged Carbamazepine Child Drug Therapy, Combination Epilepsy Female Humans Intellectual Disability Male Middle Aged Mood Disorders Psychotropic Drugs Social Behavior Disorders

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