Debra Friedman
Faculty Member
Last active: 2/12/2015

Influence of age upon Ifosfamide-induced nephrotoxicity.

McCune JS, Friedman DL, Schuetze S, Blough D, Magbulos M, Hawkins DS
Pediatr Blood Cancer. 2004 42 (5): 427-32

PMID: 15049014 · DOI:10.1002/pbc.20011

BACKGROUND - Ifosfamide-induced nephrotoxicity is well recognized in children, although it has also been reported in adults. Whether ifosfamide nephrotoxicity is more common in children than in adults is not known.

PROCEDURE - Medical records of adults and children diagnosed with sarcoma whom received ifosfamide with a cumulative dose >20 g/m(2) were evaluated. Twenty-five children (
RESULTS - National Cancer Institute Common Toxicity Criteria grade 3-4 ifosfamide-induced nephrotoxicity was present in 24 and 17% of children and adults, respectively (P = 0.58). Cumulative ifosfamide doses were similar between the two populations, with the median (range) of 70.2 g/m(2) (22.4-72) for children and 59 g/m(2) (20.8-146) for adults (P = 0.25). Logistic regression analysis indicated that neither age or cumulative ifosfamide dose were associated with grade 3-4 ifosfamide-induced nephrotoxicity (P = 0.36).

CONCLUSIONS - Children and adults receiving >20 g/m(2) of ifosfamide have similar susceptibility to ifosfamide-induced nephrotoxicity. Factors other than age and cumulative dose should be considered for understanding the inter-individual variation in nephrotoxicity.

Copyright 2004 Wiley-Liss, Inc.

MeSH Terms (21)

Adolescent Adult Aged Age Factors Antineoplastic Agents, Alkylating Child Child, Preschool Dose-Response Relationship, Drug Drug Evaluation Female Humans Ifosfamide Infant Male Middle Aged Nephrosis Regression Analysis Retrospective Studies Risk Factors Sarcoma Sarcoma

Connections (1)

This publication is referenced by other Labnodes entities: