Meira Epplein
Faculty Member
Last active: 5/5/2016

Gastric cancer: an infectious disease.

Piazuelo MB, Epplein M, Correa P
Infect Dis Clin North Am. 2010 24 (4): 853-69, vii

PMID: 20937454 · PMCID: PMC2954127 · DOI:10.1016/j.idc.2010.07.010

The role of infectious agents and chronic inflammation in carcinogenesis is being increasingly recognized. It has been estimated that about 18% of cancers are directly linked to infections, particularly gastric adenocarcinoma (Helicobacter pylori), cervical carcinoma (human papilloma viruses), and hepatocarcinoma (hepatitis B and C viruses). Multiple clinical trials of COX-2 inhibitors and other antiinflammatory agents have shown a beneficial effect on the development of diverse tumors, such as those of the colon, stomach, prostate, and breast. However, their mechanism of action is not completely understood and may differ among the infectious agents and tumor types. Because gastric adenocarcinomas account for more than 90% of all gastric malignancies, this review focuses on adenocarcinomas.

Copyright © 2010 Elsevier Inc. All rights reserved.

MeSH Terms (8)

Adenocarcinoma Gastric Mucosa Global Health Helicobacter Infections Helicobacter pylori Humans Male Stomach Neoplasms

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