Rebecca Cook
Faculty Member
Last active: 4/15/2019

Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations.

Elion DL, Cook RS
Trends Mol Med. 2018 24 (8): 655-656

PMID: 30060834 · DOI:10.1016/j.molmed.2018.06.003

Chemotherapy is the most commonly prescribed treatment for patients with aggressive and lethal triple negative breast cancers (TNBCs), which often develop chemoresistance. A recent study combined single nucleus sequencing, single cell RNA sequencing, and evolutionary biology to understand how tumor cells use genetic and phenotypic diversity to evade the selective pressures of neoadjuvant chemotherapy.

Copyright © 2018 Elsevier Ltd. All rights reserved.

MeSH Terms (5)

Antineoplastic Combined Chemotherapy Protocols Drug Resistance, Neoplasm Humans Neoadjuvant Therapy Triple Negative Breast Neoplasms

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