Rebecca Cook
Faculty Member
Last active: 4/15/2019

MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors.

Turke AB, Song Y, Costa C, Cook R, Arteaga CL, Asara JM, Engelman JA
Cancer Res. 2012 72 (13): 3228-37

PMID: 22552284 · PMCID: PMC3515079 · DOI:10.1158/0008-5472.CAN-11-3747

MeSH Terms (11)

Cell Line Enzyme Activation Feedback Flow Cytometry Gene Knockdown Techniques Mitogen-Activated Protein Kinase Kinases Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Receptor Protein-Tyrosine Kinases Reverse Transcriptase Polymerase Chain Reaction Tandem Mass Spectrometry

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