Rebecca Cook
Faculty Member
Last active: 4/15/2019

Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells.

Miller TW, Forbes JT, Shah C, Wyatt SK, Manning HC, Olivares MG, Sanchez V, Dugger TC, de Matos Granja N, Narasanna A, Cook RS, Kennedy JP, Lindsley CW, Arteaga CL
Clin Cancer Res. 2009 15 (23): 7266-76

PMID: 19934303 · PMCID: PMC2787848 · DOI:10.1158/1078-0432.CCR-09-1665

MeSH Terms (20)

Animals Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antineoplastic Agents Breast Neoplasms Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm Female Humans Intracellular Signaling Peptides and Proteins Mice Mice, SCID Neoplasms Phosphatidylinositol 3-Kinases Phosphorylation Protein-Serine-Threonine Kinases Receptor, ErbB-2 TOR Serine-Threonine Kinases Trastuzumab

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