Eduard Chekmenev
Faculty Member
Last active: 2/13/2015

Propane- Heterogeneously Hyperpolarized by Parahydrogen.

Kovtunov KV, Truong ML, Barskiy DA, Salnikov OG, Bukhtiyarov VI, Coffey AM, Waddell KW, Koptyug IV, Chekmenev EY
J Phys Chem C Nanomater Interfaces. 2014 118 (48): 28234-28243

PMID: 25506406 · PMCID: PMC4259496 · DOI:10.1021/jp508719n

Long-lived spin states of hyperpolarized propane- gas were demonstrated following pairwise addition of parahydrogen gas to propene- using heterogeneous parahydrogen-induced polarization (HET-PHIP). Hyperpolarized molecules were synthesized using Rh/TiO solid catalyst with 1.6 nm Rh nanoparticles. Hyperpolarized ( ∼ 1%) propane- was detected at high magnetic field (9.4 T) spectroscopically and by high-resolution 3D gradient-echo MRI (4.7 T) as the gas flowed through the radiofrequency coil with a spatial and temporal resolution of 0.5 × 0.5 × 0.5 mm and 17.7 s, respectively. Stopped-flow hyperpolarized propane- gas was also detected at 0.0475 T with an observed nuclear spin polarization of ∼ 0.1% and a relatively long lifetime with = 6.0 ± 0.3 s. Importantly, it was shown that the hyperpolarized protons of the deuterated product obtained via pairwise parahydrogen addition could be detected directly at low magnetic field. Importantly, the relatively long low-field of HP propane- gas is not susceptible to paramagnetic impurities as tested by exposure to ∼0.2 atm oxygen. This long lifetime and nontoxic nature of propane gas could be useful for bioimaging applications including potentially pulmonary low-field MRI. The feasibility of high-resolution low-field 2D gradient-echo MRI was demonstrated with 0.88 × 0.88 mm spatial and ∼0.7 s temporal resolution, respectively, at 0.0475 T.

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