Eduard Chekmenev
Faculty Member
Last active: 2/13/2015

LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization.

Theis T, Truong M, Coffey AM, Chekmenev EY, Warren WS
J Magn Reson. 2014 248: 23-6

PMID: 25299767 · PMCID: PMC6097635 · DOI:10.1016/j.jmr.2014.09.005

Nuclear spin hyperpolarization overcomes the sensitivity limitations of traditional NMR and MRI, but the most general method demonstrated to date (dynamic nuclear polarization) has significant limitations in scalability, cost, and complex apparatus design. As an alternative, signal amplification by reversible exchange (SABRE) of parahydrogen on transition metal catalysts can hyperpolarize a variety of substrates, but to date this scheme has required transfer of the sample to low magnetic field or very strong RF irradiation. Here we demonstrate "Low-Irradiation Generation of High Tesla-SABRE" (LIGHT-SABRE) which works with simple pulse sequences and low power deposition; it should be usable at any magnetic field and for hyperpolarization of many different nuclei. This approach could drastically reduce the cost and complexity of producing hyperpolarized molecules.

Copyright © 2014 Elsevier Inc. All rights reserved.

MeSH Terms (8)

Catalysis Hydrogen Iridium Magnetic Fields Pyridines Radiation Dosage Singlet Oxygen Spin Labels

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