Eduard Chekmenev
Faculty Member
Last active: 2/13/2015

Parahydrogen induced polarization of 1-(13)C-phospholactate-d(2) for biomedical imaging with >30,000,000-fold NMR signal enhancement in water.

Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY
Anal Chem. 2014 86 (12): 5601-5

PMID: 24738968 · PMCID: PMC4063326 · DOI:10.1021/ac500952z

The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d2, precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d2, is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d2 was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)C-phospholactate-d2 (58 ± 4 s versus 36 ± 2 s for nondeuterated form at 47.5 mT), and large production quantities (52 μmoles in 3 mL) in aqueous medium make this compound useful as a potential contrast agent for the molecular imaging of metabolism and other applications.

MeSH Terms (4)

Hydrogen Lactates Proton Magnetic Resonance Spectroscopy Water

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