Anuradha Chakravarthy
Faculty Member
Last active: 3/30/2020

DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: pilot study findings.

Li X, Arlinghaus LR, Ayers GD, Chakravarthy AB, Abramson RG, Abramson VG, Atuegwu N, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Grau AM, Sanders M, Bhave SR, Yankeelov TE
Magn Reson Med. 2014 71 (4): 1592-602

PMID: 23661583 · PMCID: PMC3742614 · DOI:10.1002/mrm.24782

PURPOSE - The purpose of this pilot study is to determine (1) if early changes in both semiquantitative and quantitative DCE-MRI parameters, observed after the first cycle of neoadjuvant chemotherapy in breast cancer patients, show significant difference between responders and nonresponders and (2) if these parameters can be used as a prognostic indicator of the eventual response.

METHODS - Twenty-eight patients were examined using DCE-MRI pre-, post-one cycle, and just prior to surgery. The semiquantitative parameters included longest dimension, tumor volume, initial area under the curve, and signal enhancement ratio related parameters, while quantitative parameters included K(trans), v(e), k(ep), v(p), and τ(i) estimated using the standard Tofts-Kety, extended Tofts-Kety, and fast exchange regime models.

RESULTS - Our preliminary results indicated that the signal enhancement ratio washout volume and k(ep) were significantly different between pathologic complete responders from nonresponders (P < 0.05) after a single cycle of chemotherapy. Receiver operator characteristic analysis showed that the AUC of the signal enhancement ratio washout volume was 0.75, and the AUCs of k(ep) estimated by three models were 0.78, 0.76, and 0.73, respectively.

CONCLUSION - In summary, the signal enhancement ratio washout volume and k(ep) appear to predict breast cancer response after one cycle of neoadjuvant chemotherapy. This observation should be confirmed with additional prospective studies.

Copyright © 2013 Wiley Periodicals, Inc.

MeSH Terms (16)

Adult Antineoplastic Agents Breast Neoplasms Chemotherapy, Adjuvant Female Humans Image Enhancement Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Middle Aged Neoadjuvant Therapy Pilot Projects Prognosis Reproducibility of Results Sensitivity and Specificity Treatment Outcome

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