Ty Abel
Faculty Member
Last active: 3/27/2014

Vascular complications of fungal meningitis attributed to injections of contaminated methylprednisolone acetate.

Kleinfeld K, Jones P, Riebau D, Beck A, Paueksakon P, Abel T, Claassen DO
JAMA Neurol. 2013 70 (9): 1173-6

PMID: 23877880 · PMCID: PMC4143418 · DOI:10.1001/jamaneurol.2013.3586

IMPORTANCE - Fungal meningitis due to injections of contaminated methylprednisolone acetate can present with vascular sequelae in immunocompetent individuals. This is particularly germane to neurologists because better recognition of the clinical characteristics of patients with fungal meningitis and ischemic stroke will provide more timely and efficient care.

OBSERVATIONS - In a case series, 3 patients presented to Vanderbilt University Medical Center in Nashville, Tennessee, with acute ischemic stroke and later received a diagnosis of fungal meningitis attributed to epidural injections of contaminated methylprednisolone. Of these 3 patients, 2 were women, and the mean age for all 3 was 75.3 years. Their medical records and imaging scans were reviewed. All 3 patients presented with acute ischemic strokes and had a history of epidural spinal injections of methylprednisolone for low back pain. All 3 patients had 1 or more traditional risk factors for stroke. There were differing vascular patterns of presentation: 2 patients presented with small-vessel (lacunar) infarctions, whereas 1 patient presented with a large-vessel infarct. Of these 3 patients, 2 died and underwent an autopsy, which revealed Exserohilum rostratum as the presumed cause of death. For 2 cases, fever and meningeal signs were absent at presentation.

CONCLUSIONS AND RELEVANCE - Patients with fungal meningitis may present with ischemic stroke detected on initial imaging scans. A definitive diagnosis should not delay early antifungal treatment.

MeSH Terms (14)

Aged Anti-Inflammatory Agents Antifungal Agents Brain Drug Contamination Female Humans Injections, Epidural Male Meningitis, Fungal Methylprednisolone Methylprednisolone Acetate Risk Factors Stroke

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